Prostate news article, February 2008
EPITHELIAL PROSTATE CELL FACTORS MAY REGULATE BPH STROMAL PROLIFERATION Prostatic epithelial cells may regulate the estradiol-stimulated proliferation and differentiation of prostatic stromal cells in BPH. Article by Liam Davenport - BJU International 2008- Forwarded by Professor Roger Kirby |
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MedWire (2/2, Davenport) reported, "Factors secreted by prostatic epithelial cells may regulate the estradiol-stimulated proliferation and differentiation of prostatic stromal cells in benign prostatic hyperplasia (BPH)," according to a study published in the February issue of the journal BJU International. For the study, researchers "added conditioned media from a prostatic epithelial cell line (BPH-1) pretreated with different concentrations of estradiol to cultures of primary prostatic stromal cells." They found that "when the stromal cells were cultured with combination media from BPH-1 cells treated with estradiol, the rate of proliferation increased, with an increase in the average cell growth fraction of 131 percent after 72 hours." But, "when stromal cells were cultured with estradiol alone or with BPH-1 combination media from untreated cells," the researchers observed "no significant changes." They also found that "treatment with combination media from BPH-1 cells increased levels of smoothelin mRNA and [smooth muscle myosin heavy chain] (SM-MHC) levels, but the increase was greater when combination media from estradiol-treated cells was used." This finding indicates "that proliferation, differentiation and extracellular matrix accumulation in prostatic stromal cells could be modified by estradiol through the regulation of epithelial cells in a paracrine manner," the researchers wrote.
The full text of this article is available here from Medwire.