| PROGRESSION
OF BPH: THE PREDICTIVE VALUE OF INFLAMMATION DETECTED
AT TRUS BIOPSY
Motaz Qadan, Alastair Lamb Western General Hospital, University of Edinburgh |
 |
Summary of aims
Benign prostatic hyperplasia (BPH) affects around half of men over 50 years old. It can significantly impact quality of life, leading to lack of sleep, tiredness, poor daytime concentration, and interruption of daytime activities. Treatments are available, but all have side-effects such as altered blood pressure, decreased libido, or the risks of surgery.
The important thing is to know in advance which men are likely to develop the more serious symptoms. Targeting these individuals with therapy would allow the disease to be controlled appropriately in advance, without exposing men unnecessarily to the potential side-effects.
This project will investigate the link between the presence of inflammation in prostate tissue and progression of BPH, with a view to focussing treatment on those individuals in whom inflammation is present.
Progress Report
Permission to access original tissue has recently been granted and all our current slides have been stained in order to allow the counting of cells. We expect these will correlate positively with those patients who have thus far demonstrated the progression criteria described above.
We are glad to report that clinical data for selected patients has now been gathered and this constitutes a significant portion of the workload of this project. We anticipate that all data including those from the specimens will be ready for analysis by the end of September 2007 and that a final report will be available by mid October 2007.
Summary of interim research report, 29 July 2007.
Project 2006/05